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Farm Comunitarios. 16(4):61-82. doi: 10.33620/FC.2173-9218.(2024).27

Selection of pharmacogenomic variants and methodology for their use in community pharmacy

Montero-Gómez A1, Sánchez Pozo A2
1. Community Pharmacist and Master in Pharmaceutical Care. Granada. 2. Professor of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada.
Montero-Gómez A, Sánchez A. Selection of pharmacogenomic variants and methodology for their use in community pharmacy. Farm Comunitarios. 16(4):61-82. doi: 10.33620/FC.2173-9218.(2024).27
Abstract : 
Regulatory agencies such as the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recognize pharmacogenetics as a key tool in their pharmacological guidelines for pharmaceutical counseling. In this context, community pharmacies play a crucial role in addressing this healthcare need, which could lead to a significant improvement in patients’ quality of life by preventing ineffective or contraindicated treatments.
 
In this work, we conducted a systematic review of the available scientific evidence regarding druggene interactions relevant to community pharmacy. We identified the main genes and polymorphisms associated with treatment response and adverse effects in primary care. Finally, we propose a model for implementing pharmacogenetic services in community pharmacies.
Keywords : 
Pharmacogenetics, Pharmacogenomics, Genotype, Adverse effects, Pharmacokinetics, Pharmacodynamics, Community pharmacy, Cytochrome P450, Genetic polymorphism, HLA

Editor: © SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. 
Copyright© SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. This article is available from url https://www.farmaceuticoscomunitarios.org/. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/

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